Define influence of polymer on buccal tablet characteristics by factorial design

A two factor three level factorial design was used to investigate the effects of carbopol and cationic hydrophilic polymers which have a common use in buccal drug formulations. Statistical modelswith interaction terms were derived to evaluate influence of carbopol(X1) and chitosan (X2) on tablet disintegration (Y1) and dissolution(Y2), mechanical properties (Y3), swelling (Y4). Tablet disintegrationstudies were carried out using two different pH environments withinbuccal region pH limits and also two different commonly used dissolutionmethods for buccal tablets were also investigated to compare the effectof polymer type on dissolution. Polymer type and ratio affect thecharacteristics of the buccal tablets due to their differentphysicochemical behavior at buccal pH. Also significant variances betweendissolution profiles for buccal tablets, using either USP Paddle or flowthrough cell methods were found. These results indicate that both polymer type and ratio as well as combination of them effects the drug behavior in different ways.

Effect of polymer type on characteristics of buccal tablets using factorial design
University of Health Sciences, Gulhane Campus, Department of Pharmaceutical Sciences, Etlik, Ankara, Turkey
Ministry of National Defense, Ankara, Turkey
Effect of polymer type on characteristic
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effects of carbopol and cationic hydrophilic polymerswhich have a common use in buccal drug formulations
Two factor three level factorial analysis design