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Dear Colleagues

Cyclodextrins (CDs) are cyclic oligosaccharides which are able to form inclusion complexes with a variety of hydrophobic guest molecules, and are mainly utilized in the pharmaceutical field to enhance the water solubility and dissolution rate of poorly-soluble drugs, to mask unpleasant taste or odor, improve the stability of the included host molecules from hydrolysis or enzymatic degradation in the gastric environment, and reduce local drug irritation phenomena. Vice versa, hydrophobic cyclodextrins could represent suitable carriers for obtaining slow-dissolving profiles of soluble drugs. The addition of small amounts of some hydrophilic polymers and the application of different solid dispersion preparation methods can significantly increase the CD solubilising and complexing abilities through the formation of ternary drug–CD–hydrophilic polymer complexes.Cyclodextrins can be successfully applied to improve drug entrapment and drug release and permeation properties from several kinds of conventional or less-conventional drug delivery systems, thus simultaneously exploiting both cyclodextrin complexation and drug delivery systems properties.

Prof. Francesca Maestrelli

Dr. Marzia Cirri

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