Mucoadhesion: A promising approach in drug delivery system

Mucoadhesion, the state in which two materials, amongst which one is biological in nature, adhere to each other for extended periods of time with the help of interfacial forces, provides an attractive strategy to overcome the hurdles of conventional drug delivery systems including first pass metabolism, and localized delivery of biomolecules including proteins, peptides and oligonucleotides. Mucoadhesion provides great opportunities for the delivery of a variety of compounds via different routes of administration viz. ocular, nasal, vaginal and buccal. In addition mucoadhesion also makes it possible to obtain prolonged, local or systemic drug action. In this review we discussed about potential applications of mucoadhesion and mucoadhesive polymers in drug delivery along with the mechanism of mucoadhesion and the methods for evaluation of mucoadhesive drug delivery systems.


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Formulation Development and Evaluation of Sustained Release Matrix Tablets of Vildagliptin - Synthetic and Natural Polymers

Formulation Development and Evaluation of Sustained Release Matrix Tablets of Vildagliptin - Synthetic and Natural Polymers
Y. Ganesh Kumar1,2, J. Sreekanth3, D. Satyavati2
1Research Scholar, Department of Pharmaceutics, Jawaharlal Nehru Technological University, Kukatpally,
Hyderabad, Telangana, India, 2Department of Pharmaceutics, Brilliant Group of Institutions (Integrated
Campus), Abdullapurmet, Hayathnagar, Telangana, India, 3R&D Center, MSN Laboratories Pvt. Ltd,
Hyderabad, Telangana, India
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Formulation and Evaluation of Mucoadhesive Thermosensitive in situ Gel of Tenofovir Disoproxil Fumarate for Pre-Exposure Prophylaxis Against HIV

Pre-exposure prophylaxis (PrEP) is one of the best preventive strategies in protection against HIV/AIDS. The present research approach is development of novel topical thermosensitive mucoadhesive in situ gel for intravaginal use. Tenofovir disoproxil fumarate (TDF) has been loaded in the formulation and cold method was followed to prepare the various formulations.


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Global OSDF Excipients Demand to Grow at 4.5% CAGR to 20

Demand will be driven by the growth of the global pharmaceutical market amid increasing aging population, coupled with the development and introduction of new excipients that exhibit improved properties such as flowability.

Posted on 29 January 2014 by Stephen Las Marias



Eyes On Excipients

Inactive but essential drug ingredients are getting checked out with modern rigor to ensure their quality
Chemical and Engineering News

Volume 92 Issue 5 | pp. 9-11

Issue Date: February 3, 2014