Comparing Drug Layering and Direct Pelletization Processes
The extended-release performance of drug-loaded pellets manufactured by two methods, drug layering and direct pelletization, was compared.
Mar 02, 2014 by Ed Godek  - Pharmaceutical Technology
FORMULATION DEVELOPMENT OF MOUTH DISSOLVING FILM OF ETORICOXIB FOR PAIN MANAGEMENT
Etoricoxib is a potent, orally active, highly selective COX-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities. The present research was undertaken to develop Mouth Dissolving Films of Etoricoxib to have rapid onset of action.
Platform Formulation Development Using a Novel Pulmonary Excipient and In Vivo Evaluation of a Model Formulation of Fluticasone Propionate
David T. Vodak1, Dwayne Friesen1, Dan E. Dobry1, Philip J. Kuehl2, Melanie Doyle-Eisele2, Jacob D. McDonald2, Warren K. Miller1, and David K. Lyon1
(1. Bend Research Inc., 64550 Research Rd., Bend, Oregon 97701 U.S.A.▪541-382-4100▪www.bendres.com; 2. Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. S.E., Albuquerque, New Mexico 87108 U.S.A.▪www.lrri.org▪505-348-9400)
Formulation and Evaluation of Bilayer Tablets of Glimepiride and Metformin HCL
Pamu. Sandhya1, 2, Faheem Unnisa Begum1, Afreen1
1Department of Pharmaceutics, Shadan Womens College of Pharmacy, 500 004, Hyderabad, India 2University College of Technology, Osmania University, Hyderabad, 500 007, India
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
e-ISSN: 2278-3008, p-ISSN:2319-7676. Volume 9, Issue 1 Ver. IV (Jan. 2014), PP 38-45
Evidence-Based Nanoscopic and Molecular Framework for Excipient Functionality in Compressed Orally Disintegrating Tablets
Ali Al-khattawi1,3, Hamad Alyami1, Bill Townsend2,3, Xianghong Ma2,3, Afzal R. Mohammed1,3*
1 Aston School of Pharmacy, Aston University, Birmingham, United Kingdom, 2 School of Engineering and Applied Science, Aston University, Birmingham, United
Kingdom, 3 Aston Research Centre for Healthy Ageing, Aston University, Birmingham, United Kingdom
EXPLORATION OF NOVEL CO-PROCESSED MULTIFUNCTIONAL EXCIPIENT FOR TABLET DOSAGE FORM
Digesh D. Shah, Rajnikant M. Suthar*, Ajay B. Sola
The aim of the present investigation is to formulate novel co-processed multifunctional excipient for tablet dosage form. Co- processed particles of chitosan, microcrystalline cellulose (MCC) and aerosil-200 were fabricated by wet granulation technique to be used as a directly compressible excipient in tablet formulation. The developed co-processed excipients (CPE) were evaluated for their excipient related and dosage form related parameters. As expected, all the prepared batches exhibited acceptable angle of repose (<350) and quick disintegration time (<1min). The intimate physical association between chitosan, MCC and aerosil-200 has created an insoluble, hydrophilic, highly absorbent material, resulting in superiority in water uptake, water saturation for gelling formation, and compactability among other superdisintegrants. The developed CPE could be act as a superdisintegrant and pharmaceutical filler at the same time.
Optimization Direct Compression’s Co-Processed Excipient Microcrystalline Cellulose PH 102 and Povidone® K 30
*Aris Perdana Kusuma1,2, Achmad Fudholi2, Akhmad Kharis Nugroho2
1(Dept. of Pharmacy, Islamic University of Indonesia, Yogyakarta, Indonesia)
2(Pharmacy Faculty, Gadjah Mada University, Yogyakarta, Indonesia)
Reduction of Bitterness and Enhancing Palatability of Cetirizine Oral Liquid Dosage Forms by Cyclodextrins
Ali M1, EL-Massik MA1, Abdallah OY2 and Abdelkader H*3
1Department of Pharmaceutics, Faculty of Pharmacy, Pharos University, Alexandria, Egypt
2Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
3Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt
Ternary solid solutions, obtained by hot melt extrusion (hme) of itraconazole in a binary matrix
K.W. Chooi1,2, J. Fraser2, D.S. Jones1 and G.P. Andrews1
1School of Pharmacy, Queen’s University Belfast, Belfast, UK. 2Encap Drug Delivery, A division of Capsugel® Dosage Form Solutions, Livingston, UK.
At the request of FDA and with their input, IPEC-Americas and IPEC Europe have developed a position paper on the need and procedure for establishing the complete supply chain history of an excipient for use in pharmaceuticals, e.g., the excipient's "pedigree.
LIPID BASED DRUG DELIVERY SYSTEM: CLASSIFICATION, DRUG TRANSPORT ACROSS ENTEROCYTE, ROLE OF LIPID CHAIN LENGTH IN SUPPRESSION OF BODY FAT ACCUMULATION
Md. Habban Akhter1*, Govind Mohan1, Md. Hedaitullah2, Md. Khalid Iqbal2
1NIMS Institute of Pharmacy, NIMS University P.O. Box 303121, Jaipur, India.
2HIMT College of Pharmacy, Greater Noida (U.P), India.
Md. Habban Akhter et al. / International Journal of Pharmacy, 4(2), 2014, 98-108.