21. September 2017
Free Webinar Thu, Jan 25, 2018 6:00 PM - 7:00 PM CET Information & Registration
21. September 2017
Cross-linking is a common problem in the dissolution of gelatin capsules. Cross-linking is characterized by a bridge across the peptide backbone of the gelatin molecule which creates water insoluble membranes or pellicles during dissolution testing. The chemical covalent bonding between gelatin chains is typically triggered by catalytic amounts of aldehyde and/or from exposure to high temperature and humidity.
21. September 2017
The objective of this study was to prepare time-controlled release etodolac pellets to facilitate drug administration according to the body’s biological rhythm, optimize the drug’s desired effects, and minimize adverse effects.
20. September 2017
The 2018 Formulation and Drug Delivery USA Congress will take place from 12th to 13th March in San Diego
Over 40 case studies and presentations will focus on exploring regulatory guidelines of both large and small molecule formulations, future applications of protein and peptide formulations, recent advancements in nanoparticles as drug delivery systems, combination drug delivery devices and improving the bioavailability of compounds will be discussed.
20. September 2017
Technology platform allows rapid and efficient screening of formulations consisting of different excipients to minimize aerosolization-induced protein aggregation
Aerosolized administration of biopharmaceuticals to the airways is a promising route for nasal and pulmonary drug delivery, but − in contrast to small molecules − little is known about the effects of aerosolization on safety and efficacy of biopharmaceuticals. Proteins are sensitive against aerosolization-associated shear stress. Tailored formulations can shield proteins and enhance permeation, but formulation development requires extensive screening approaches. Thus, the aim of this study...

excipient · ​stability · ​permeation · ​nebulizer · ​aggregation · ​Antibodies · ​scaffolds · ​sep2017 · ​aerosolization · ​airways · ​airliquid · ​interface

20. September 2017
 Eudragit® FS 30D and hydroxypropyl methylcellulose (HPMC) were used as pH-dependent and time-dependent polymers
Abstract The objective of this study was to evaluate the combination of pH-dependent and time-dependent polymers on drug release in order to optimize coating for colonic delivery. Response surface methodology (RSM) based on central composite design (CCD) was employed for formulation optimization. Theophylline was used as model drug and Eudragit® FS 30D and hydroxypropyl methylcellulose (HPMC) were used as pH-dependent and time-dependent polymer, respectively. Dissolution test was carried out...

excipient · ​delivery · ​imaging · ​surface · ​Response · ​methodology · ​FS · ​Hydroxypropyl · ​methylcellulose · ​Eudragit® · ​Colon · ​30 · ​D · ​sep2017 · ​Xray

19. September 2017
Fluid bed coating offers potential advantages as a formulation platform for amorphous solid dispersions (ASDs) of poorly soluble drugs, being a one-step manufacturing process which could reduce therisk of phase separation associated with multiple step manufacturing approaches. However, the impact of the physicochemical nature of carrier spheres on the properties and drug release from the ASDshas not been studied in detail. In this work, tartaric acid (TAP) and microcrystalline cellulose (CEL)...

excipient · ​drug · ​delivery · ​coating · ​cellets · ​pellets · ​acid · ​multiparticulate · ​fluidbed · ​tartaric · ​tap · ​sep2017

18. September 2017
Multiparticulate formulation development
the present investigation was to develop a multiparticulate modified release system of methylphenidate hydrochloride (HCl) generating biphasic release profile from single core.
18. September 2017
Cigarette smoking has become one of the leading causes of preventable deaths all over the world, causing a serious threat to human wellbeing and a tremendous economic burden to governments. The currently available treatment options for smoking cessation are not efficient. The pulmonary delivery of drugs by methods such as dry powder inhaler (DPI) has been recognized as one of the most efficient routes of drug delivery to the targeted area. The lung delivery of nicotine in this way would be
17. September 2017
The flow properties of StarCap1500 are ideal for capsule filling applications
StarCap 1500 is a unique co-processed mixture of globally accepted excipients, corn starch and pregelatinized starch, designed for use in capsules and tablets. StarCap 1500 is an inert free-flowing compressible excipient with excellent disintegration characteristics. The flow properties of StarCap1500 are ideal for capsule filling applications. StarCap 1500 flows smoothly with minimal dusting or adherence to contact surfaces. This corresponds to a cleaner filling operation with lower variation...

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