Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system

Efficient topical drug delivery systems of norfloxacin have been synthesized. Norfloxacin loaded to the core of lipid- polymer hybrid nanoparticles were prepared. The formulations were optimized by factorial design and characterization techniques. A unique formulation of norfloxacin that offer prolonged and control delivery.

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A 30-Year History of PLG Applications in Parenteral Controlled Drug Release

Poly(lactide-glycolide) has been used for drug-delivery applications because of its beneficial physicochemical properties, long safety record, and reliable commercial supply.

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Applications and biotechnological production of mannitol

Attention on mannitol production by fermentation is received in recent years. Fermentation factors affected the mannitol yield are listed. Mannitol applications in food, pharmaceutical and chemical industries are reviewed.

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Saturated phosphatidylcholine as matrix former for oral extended release dosage forms

The aim of this study was to evaluate the suitability of saturated phosphatidylcholine (Phospholipon® 90H) as extended release excipient in matrix tablets for three model drugs with different aqueous solubility (theophylline, caffeine and diprophylline)

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Challenges in oral peptide delivery: lessons learnt from the clinic and future prospects

Therapeutic peptides have become very successful drugs due to their specificity, potency and low toxicity, but they show challenges for their delivery, due to their short half-life and rapid plasma clearance.

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Effect of directly compressible excipient and treated agar on drug release of clopidogrel oral disintegrating tablets

In the present investigation, oral dissolving/dispersible/disintegrating tablets (ODTs) of clopidogrel were designed with a view to enhance the bioavailability and patient compliance by two different methods, namely, direct compression and effervescent methods using directly compressible excipient and treated agar (TAG)

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In Situ Salification in Polar Solvents: a Paradigm for Enabling Drug Delivery of Weakly Ionic Drugs as Amorphous Solid Dispersion

Solubility challenge for a poorly water-soluble drug gets further intensified when it is weakly ionic because the most common solubility enhancement technique, salt formation, becomes less feasible.

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Development of a Novel Polymeric Nanocomposite Complex for Drugs with Low Bioavailability

Semi-synthetic biopolymer complex (SSBC) nanoparticles were investigated as a potential oral drug delivery system to enhance the bioavailability of a poorly water-soluble model drug acyclovir (ACV).

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Science of Stability - 3rd Annual Conference 2017

The conference will expose attendees to the latest discoveries and innovations in the science of stability across different industries including pharmaceuticals, generics, nutraceuticals, OTCs and consumer products. This is a must-attend program for everyone interested in accelerated aging, degradation chemistry and stability.

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How to identify and manage ‘problem’ excipients in medicines for children

Children may be exposed to potentially harmful excipients, essential components of drug formulations, through unlicensed and off-label use of adult medicines. Excipient exposure should be minimised, although a medicine containing a problem excipient may be indicated, but only after a careful risk–benefit assessment.

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