Co-release of paclitaxel and encequidar from amorphous solid dispersions increase oral paclitaxel bioavailability in rats
The oral bioavailability of paclitaxel is limited due to low solubility and high affinity for the P-glycoprotein (P-gp) efflux transporter. Here we hypothesized that maximizing the intestinal paclitaxel levels through apparent solubility enhancement and controlling the simultaneous release of both paclitaxel and the P-gp inhibitor encequidar from…
Novel Microemulsion Containing Benzocaine and Fusidic Acid Simultaneously: Formulation,…
Modern drug carrier technologies, such as microemulsions with small droplet sizes and high surface areas, improve the ability of low water solubility active ingredients to permeate and localize. The goal of this study was to create…
Simple preparation and greatly improved oral bioavailability: The supersaturated drug delivery…
Quercetin, as a representative flavonoid, is widely present in daily diet and has been developed as a dietary supplement due to its beneficial physiological activities. However, the application of quercetin is limited due to its poor water…
From Seed to Solution: The Unrivaled Quality of ADM Refined Sesame Oil IV-1 in Pharma
ADM Refined Sesame Oil IV-1 is a highly purified sesame oil, fully compliant with the:
"European Pharmacopoeia (0433) and United States Pharmacopeia/National Formulary (USP/NF) monographs and general notices"
intended for use in…
Evonik makes five generations healthier with EUDRAGIT® coatings for targeted drug delivery
PRESS RELEASE
Evonik Health Care Essen, Germany, March 14, 2024
EUDRAGIT® polymers have been used as coatings to create more effective drugs for 70 years. Over the decades, the portfolio of methacrylate polymers has…
Evaluation of the effect of polymer composition on the rheological, mechanical properties and drug…
Capsules have been investigated as a popular oral dosage form among communities due to their simplicity and ease of production. Capsules that are considered in the gastro-resistance category can be very beneficial due to enhanced drug…
Study of PEG-b-PLA/Eudragit S100 Blends on the Nanoencapsulation of Indigo Carmine Dye and…
A nanocapsule shell of poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) mixed with anionic Eudragit S100 (90/10% w/w) was previously used to entrap and define the self-assembly of indigo carmine (IC) within the hydrophilic…
Aqueous remote loading of model cationic peptides in uncapped poly(lactide-co-glycolide)…
Remote loading microencapsulation of peptides into polymer microspheres without organic solvent represents a promising alternative to develop long-acting release depots relative to conventional encapsulation methods. Here, we formulated…
Polymers for Pharmaceutical and Biomedical Applications – New Interesting Book
See the new book, edited by Vandana Patravale, John Disouza and Aliasgar Shahiwala.
Key Features
Explains fundamental concepts relating to the synthesis, modification, and characterization of polymers
Guides the reader…
Pulsatile Drug Delivery Systems of Esomeprazole: Optimization through Quality by Design
Abstract
Background:
The current research work was aimed to optimize and develop Pulsatile Drug Delivery Systems (PDDS) of esomeprazole so as to control the nocturnal acid breakthrough in ulcer patients.
Materials and Methods:…
Supersaturable diacyl phospholipid dispersion for improving oral bioavailability of brick dust…
This study aims to investigate the potential use of polymer inclusion in the phospholipid-based solid dispersion approach for augmenting the biopharmaceutical performance of Aprepitant (APT). Initially, different polymers were screened…
Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw…
Abstract
Hydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet granulation. However, a non-homogeneous API distribution over sieve…
Precision in Every Drop: The Potential of Refined Soybean Oil in Lipophilic Drugs
ADM´s Refined Soybean Oil IV is a highly purified soybean oil fully compliant with the:
"European Pharmacopoeia (1473) and United States Pharmacopeia/National Formulary (USP/ NF) monographs and general notices"
intended for use…
Optimization of Hydroxypropyl Methylcellulose (HPMC) and Carbopol 940 in Clindamycin HCl Ethosomal…
Clindamycin HCl has anti-acne properties because it can inhibit the growth of Propionibacterium acnes (P. acnes) bacteria. However, the bioavailability of clindamycin HCl is less than 13% of the given dose, so it needs to be developed in…
Substrate-free dissolving microneedles with barbed shape to increase adhesion and drug-delivery…
Abstract
Microneedle drug delivery has recently emerged as a clinical method, and dissolving microneedles (DMNs) offer exclusive simplicity and efficiency, compared to the other kinds of microneedles. The tips of most currently available…
Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity
Abstract
Cocrystallization is an effective method for altering the tableting performance of crystals by modifying their mechanical properties. In this study, cocrystals of ligustrazine (LIG) with malonic acid (MA) and salicylic acid (SA)…
Advanced analysis of disintegrating pharmaceutical compacts using deep learning-based segmentation…
Abstract
The mechanism governing pharmaceutical tablet disintegration is far from fully understood. Despite the importance of controlling a formulation's disintegration process to maximize the active pharmaceutical ingredient's…
Enhancement of inhaled micronized powder flow properties for accurate capsules filling
Introduction
Dry powder inhalers (DPI) are gaining popularity in the field of pulmonary treatments due to their numerous advantages. Compared to pressurized metered-dose inhalers (pMDI), soft-mist inhalers (SMI), and nebulizers, which…
A new insight into the mechanism of the tabletability flip phenomenon
Abstract
Tabletability is an outcome of interparticulate bonding area (BA) – bonding strength (BS) interplay, influenced by the mechanical properties, size and shape, surface energetics of the constituent particles, and compaction…
A systematic investigation of external lubrication of mini-tablets on a rotary tablet press with…
Abstract
External lubrication is an alternative to internal lubrication and its related detrimental effects on properties of tablets like tensile strength (TS). However, to date there are hardly any systematic investigations on external…
SEPITRAP™ offers new possibilities for formulation and improving the bioavailability of active…
Description
SEPITRAP™ is a micro-encapsulated solubilizer in powder form designed to simplify the manufacturing of solid oral form drugs. It is manufactured by adsorption of the solubilizer in liquid form on a porous support.…
See the Rotative Tablet Press Machine CPR-22 from Bonapace
In the realm of pharmaceutical manufacturing, efficiency and precision are paramount. The CPR-22 tablet press from Bonapace emerges as a beacon of innovation, offering a cutting-edge solution tailored to the unique demands of the industry.…
Fabrication of Orally Fast Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze…
Abstract
Introduction: The development of a novel dosage form for cannabis extract is necessary to improve drug delivery
and to also enhance patient convenience.
Methods: Orally fast disintegrating wafer tablets containing cannabis…
Effects of excipients on the interactions of self-emulsifying drug delivery systems with human blood…
Due to its versatility in formulation and manufacturing, self-emulsifying drug delivery systems (SEDDS) can be used to design parenteral formulations. Therefore, it is necessary to understand the effects of excipients on the behavior of…
Development of Lipid-based SEDDS Using Digestion Products of Long-chain Triglyceride for High Drug…
A self-emulsifying drug delivery system (SEDDS) containing long chain lipid digestion products (LDP) and surfactants was developed to increase solubility of two model weakly basic drugs, cinnarizine and ritonavir, in the formulation. A…
Chrono-tailored drug delivery systems: recent advances and future directions
Abstract
Circadian rhythms influence a range of biological processes within the body, with the central clock or suprachiasmatic nucleus (SCN) in the brain synchronising peripheral clocks around the body. These clocks are regulated by…
Formulation Development of Solid Self-Nanoemulsifying Drug Delivery Systems of Quetiapine Fumarate…
Abstract
Quetiapine fumarate (QTF) was approved for the treatment of schizophrenia and acute manic episodes. QTF can also be used as an adjunctive treatment for major depressive disorders. QTF oral bioavailability is limited due to its…
Equivalence assessment of creams with quali-quantitative differences in light of the EMA and FDA…
Abstract
EMA and FDA are upgrading guidelines on assessing the quality and the equivalence of topically applied drug products for developing copies of originator products and supporting post-marketing variations. For topical products…
High loading of lipophilic compounds in mesoporous silica for improved solubility and dissolution…
Loading poorly soluble active pharmaceutical ingredients (API) into mesoporous silica can enable API stabilization in non-crystalline form, which leads to improved dissolution. This is particularly beneficial for highly lipophilic APIs (log…
Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a…
As a high number of active pharmaceutical ingredients (APIs) under development belong to BCS classes II and IV, the need for improving bioavailability is critical. A powerful approach is the use of lipid-based formulations (LBFs) that…
Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics
Abstract
Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations are easier to ingest, they lack the capacity to localize therapeutics with excipients nor act as controlled release devices. Here we…
Application of 3D printing technology for the development of dose adjustable geriatric and pediatric…
Abstract
Developing safe and effective formulations for the geriatric and pediatric population is a challenging task due to issues of swallowability and palatability. The lack of standardized procedures for pediatric formulations further…
Formulation development of methotrexate lipid-based nanogel for treatment of skin cancer
Skin cancer (SC) represents a prevalent malignancy worldwide, characterized by its high drug resistance and limited therapeutic efficacy with conventional treatments. Nanoparticles have emerged as promising vehicles for targeted drug…
Interplay of Drug–Polymer Interactions and Release Performance for HPMCAS-Based Amorphous Solid…
The interplay between drug and polymer chemistry and its impact on drug release from an amorphous solid dispersion (ASD) is a relatively underexplored area. Herein, the release rates of several drugs of diverse chemistry from hydroxypropyl…
The Effect of Microcrystalline Cellulose–CaHPO4 Mixtures in Different Volume Ratios on the…
Abstract
Using microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable…