Photo of manufacturing unit with in-line particle size and moisture measurement facilities
18. November 2017
by Innopharmatechnology & Glatt @ PMEC India 2017 Learn about the latest Process Analytical Technology (PAT) technical and application developments for in-line PSD and Moisture measurement in fluid bed batch and continuous powder processes. More

18. November 2017
The objective of the present study was to develop rectal mucoadhesive hydrogels loaded with Tolmetin Sodium, a non-steroidal anti-inflammatory drug, for prolonged duration of action and increased bioavailability. Fourteen formulae were prepared with different types and concentrations of polymers as hydroxypropylmethyl cellulose, hydroxylethyl cellulose, carboxymethyl cellulose and sodium alginate. Each formulation contain Tolmetin Sodium equivalent to 5% w/w active drug. The effect of the...

18. November 2017
The behaviour of proteins (β-lactoglobulin (βlg) and soy protein isolate (SPI)) and a surface active polysaccharide (hydroxypropylmethylcellulose, HPMC) o/w interfacial films under simulated gastrointestinal conditions using the interfacial tensiometer Octopus were compared and related to the performance of the emulsions (using the same emulsifiers) under in vitro digestion. The evolution of interfacial tension (γ) was used to investigate the effect of gastrointestinal fluids on o/w...
18. November 2017
The aim of the present investigation is to produce rapidly disintegrating laminar extrudates for delivering ibuprofen in the mouth of paediatric patients. is laminar shape is particularly convenient for drug delivering in the mouth and can be easily cut in cut in di erent sizes allowing for a convenient adjustment of the drug dose depending on the age of the patient. Due to the fact that in paediatric formulations, the selection of the excipients is always a challenging issue and the reduction...

17. November 2017
Pharmaceutical excipients are substances other than the pharmacologically dynamic medication or prodrug which are incorporate into the assembling procedure or are contained in a completed pharmaceutical item measurements form.
Graphic with development steps for orodispersible film of donepezil
17. November 2017
Three versatile formulations (F1, F2, and F3) of orodispersible films (ODFs) containing donepezil hydrochloride were prepared from cellulose derivatives by solvent casting technique for the treatment of Alzheimer’s disease.

Overview graphic about topics in excipient safefty in pediatrics
16. November 2017
A public workshop entitled "Challenges and strategies to facilitate formulation development of pediatric drug products" focused on current status and gaps as well as recommendations for risk-based strategies to support the development of pediatric age-appropriate drug products. Representatives from industry, academia, and regulatory agencies discussed the issues within plenary, panel, and case-study breakout sessions.

5 Steps to excipient GMP conformance are shown with short explanation
16. November 2017
Making a case for GMP certification of an excipient manufacturer should be a straightforward exercise since the benefits appear so clear cut and regulatory guidance in the EU underscores the value of certification. Specifically, Chapter 3 of the EMA Guidance on formalized risk assessments to determine the appropriate GMP for a pharmaceutical excipient states that “certification of quality systems and/or GMP by the excipient manufacturer and the standards against which these have been granted...

Graphic with list of amorphous solid dispersions and FDA approval date
15. November 2017
Poor water-solubility remains a typical property of drug candidates in pharmaceutical development pipelines today. Various processes have been developed to increase the solubility, dissolution rate, and bioavailability of these active ingredients belonging to biopharmaceutical classification system (BCS) II and IV classifications. Since the early 2000s, nanocrystal delivery and amorphous solid dispersions are more established techniques to overcome the limitations of poorly-water soluble drugs..

15. November 2017
The purpose of this study was to explore poly(vinylpyrrolidone-co-vinyl acetate) (PVP VA64) as a novel release-modifier to tailor the drug release from ethylcellulose (EC)-based mini-matrices prepared via hot melt extrusion (HME). Quetiapine fumarate (QF) was selected as model drug. QF/EC/PVP VA64 mini-matrices were extruded with 30% drug loading.

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