18. June 2018
Gelucire® is Gattefossé’s brand of semi-solid excipients originally designed for hard gelatin capsule molding. The name results from the fusion between « gélule » meaning capsule and « cire » meaning wax. Following the name, there is a set of two figures: the first (eg 44) indicates the melting point in Celsius degree, the second (eg 14) indicates the theoretical HLB (Hydrophilic Lipophilic balance). The family is composed of four products with their own characteristics, specificities...

18. June 2018
As April 2018 breezed past with news of Novartis’ US$ 8.7 billion buyout of AveXis, May set the temperatures soaring with one of the largest pharma acquisitions in recent years. Japanese drugmaker Takeda Pharmaceutical agreed to buy British drugmaker Shire for US$ 62 billion (£45.3 billion) in the biggest pharma M&A deal of the year. In a month that witnessed extensive deal making, Eli Lilly announced its commitment to spend over US$ 2.2 billion to acquire immuno-oncology companies —...

AquaPolish® containing TiO2
17. June 2018
For decades, TiO2 is used as a white pigment due toits very high opacity and brightness. Therefore, it has a wide range of applications, from colouring ingredient of pharmaceutical film coating, to food application colouring. On the basis of current discussions on a new classification and labelling of TiO2 and EFSA’s re-evaluation of TiO2 (E171) as a food additive, BIOGRUND is committed to offer alternatives for common film coating formulations.

Overview of a continous wet granulation tableting process
16. June 2018
The pharmaceutical industry is undergoing a significant change in product development and manufacturing strategies with the progressive shift from batch to continuous processes. These typically feature vast volumes of data generated by the numerous sensors connected to several unit operations running over the period of several hours or even days and that demand the application of increasingly efficient tools for process understanding, monitoring and control. This paper describes the use of...

Overview of the bioavailabilty data for two different ways of drug adminstration
15. June 2018
Semisolid self-microemulsifying drug delivery system (SMEDDS) with optimized drugloading capacity, stability, dispersibility in aqueous media and invitro drug release profile, was evaluated in vivo regarding effects on pharmacokinetics of acyclovir, an antiviral with low bioavailability (BA) and short half-life (t1/2). Additional goal of this study was evaluation of safety of this semisolid SMEDDS consisted of medium chain length triglycerides (oil) (10% w/w), macrogolglycerol hydroxystearate...

15. June 2018
This study explores the influence of different synthesis methods and drying conditions in the preparation of sodium alginate-derivate xerogels presenting interesting disintegrant functionalities. Xerogels containing alginic acid (AA) or calcium alginate (CaA) and a mixture of both, AA/CaA, were isolated using two different drying methods oven and rotary evaporation. AA showed the best wettability behavior, in contrast to the rigid crosslinked CaA structure which showed a limited rate of water...

14. June 2018
The brand new Glatt TwinPro® is absolutely revolutionary. It combines two previously single batch processes into one single process: High Shear Granulation and Fluidized Bed Drying. Critical aspects like product Transfer and wet sieving are eliminated, process time is enormously shortend. Glatt TwinPro® - Innovation by Experience. TwinPro® is the winner of the Achema 2018 Innovation Award - Category Pharmaceutical Technologies.
14. June 2018
The pharmaceutical industry has found new applications for the use of continuous processing for the manufacture of new therapies currently in development. The transformation has been encouraged by regulatory bodies as well as driven by cost reduction, decreased development cycles, access to new chemistries not practical in batch, improved safety, flexible manufacturing platforms, and improved product quality assurance. The transformation from batch to continuous manufacturing processing is the...

Graphic which shows eight different typical components of a protein formulation
12. June 2018
Preservatives are excipients essentially needed in pharmaceutical multi-dose formulations to prevent microbial growth. Among available substances, phenol is widely used for parenterals, however, it is known to interact with non-ionic surfactants like polysorbate and potentially with the active pharmaceutical ingredient. Although the need for combinations of surfactants and preservatives is growing, to date possible molecular interactions which can eventually weaken the stability and...

12. June 2018
Excipients form a major component of pharmaceutical formulations and are classified as any ingredient other than the active ingredient which is included within the product formulation to improve drug product performance. Functional uses of excipients include improving solubility and stability, safety and efficacy, as bulking agents in lyophilized formulations, tonicity agents, and aiding in controlled or prolonged drug delivery. Parenteral formulations are sterile, pyrogen-free; free of...

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