18. February 2018
Abstract Selective laser sintering (SLS) is a three-dimensional printing (3DP) technology employed to manufacture plastic, metallic or ceramic objects. The aim of this study was to demonstrate the feasibility of SLS to fabricating novel solid dosage forms with accelerated drug release properties, and with a view to create orally disintegrating formulations. Two polymers (hydroxypropyl methylcellulose (HPMC E5) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon® VA 64)) were separately...

17. February 2018
Abstract Pharmaceutical excipients were designed originally to be pharmacologically inert. However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmacokinetics. Pharmacokinetic interactions may be caused by modulation of efflux transporter proteins, intercellular tight junctions and/or metabolic enzyme amongst others. In this study, five disintegrants from different chemical classes were evaluated for P-glycoprotein (P-gp) related inhibition and tight...

16. February 2018
Here you find some abstracts of Engineering of "Biomaterials for Drug Delivery Systems - beyond Polyethylene Glycol". 1 – PEGylated “stealth” nanoparticles and liposomes Through nanomedicine, game-changing methods are emerging to deliver drug molecules directly to diseased tissue. The targeted delivery of drugs and imaging agents via drug carrier-based platforms is among the most promising of these methods. Such drug delivery systems can now be synthesized from a wide range of different...

clear gelatin capsules filled with TBA
16. February 2018
A common obstacle encountered in the early stages of drug development is the formulation of poorly water-soluble drugs (PWSDs). One effective approach to improve the dissolution of PWSDs is to render such drugs into their amorphous or disordered form.

15. February 2018
The poor oral bioavailability of many active pharmaceutical ingredients (APIs) resulting from low solubility is one of the important challenges in pharmaceutical technology. Over the last two decades the number of relatively insoluble drugs has grown steadily. Nowadays it is estimated that approximately 70% of new drug candidates are characterized by poor solubility.

15. February 2018
Location: Anywhere in the Continental USA Compensation: $100-120K base salary plus 60% bonus potential and car Date: February 2018 Job Code: TH919AEP

15. February 2018
Polymer physical gels have been used in numerous practical applications within food processing, chemical, cosmetics, pharmaceutical and agricultural industries. They may be obtained on the bases of synthetic and natural polymers. Natural polymers are easily biodegradable, hence their more extensive usage within the areas where synthetic polymers have been applied so far.

Results of analysis of drug adhesion in relation to oral dosage form
14. February 2018
Solid oral dosage forms (SODF) are drug vehicles commonly prescribed by physicists in primary and secondary cares, as they are the most convenient for the patient and facilitate therapy management. Concerns regarding unintended adhesion of SODF during oro-esophageal transit remain, especially in multimorbid patients, bedridden patients and patients suffering from dysphagia.

Photos of production of the excipient and of the analysis results of solid lipid nanoparticles
14. February 2018
The aim of the current investigation was to develop solid lipid nanoparticles of olmesartan medoxomil using hot homogenization method to improve its oral bioavailability. Central composite design was applied to optimize the formulation variables; lipid X1 (Glyceryl monostearate) and surfactant X2 (Poloxamer: Tween 80).

Graphic which shows the use of nanoparticles to go through the mucus
13. February 2018
Mucus is a highly hydrated viscoelastic gel present on various moist surfaces in our body including the eyes, nasal cavity, mouth, gastrointestinal, respiratory and reproductive tracts. It serves as a very efficient barrier that prevents harmful particles, viruses and bacteria from entering the human body.

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