19. February 2018
Solubility is the biggest challenge in the drug formulation processes. Register for the webinar Feb. 22, 11 AM EST as Kevin O'Donnell and I introduce our AFFINISOL™ and ENTERACT™ polymers for solubility enhancement and enteric delivery. http://bit.ly/2svU5Kq More on Dow Pharma Solutions

Novel ethylcellulose-based dry-coating system to obtain drug-loaded pellets
19. February 2018
The objective of this study was to assess the efficacy and the capability of a novel ethylcellulose-based dry-coating system to obtain prolonged and stable release profiles of caffeine-loaded pellets. Lauric and oleic acids at a suitable proportion were used to plasticize ethylcellulose. The effect of coating level, percentage of drug loading, inert core particle size, and composition of the coating formulation including the anti-sticking agent on the drug release profile were fully...

Graphic with production steps to integrate fenofibrate nanocrystals into a thin film
19. February 2018
The aim of the present study was to make a fenofibrate (FNB) nanocrystal (NC) by wet media milling, characterizations and formulates into oral strip-films (OSFs). Mechanical properties, redispersion study, and solid-state characterizations results suggested that reduction of drug crystal size at nanoscale and incorporation into OSFs does not affect the solid-state properties of the drug. In vitro dissolution kinetics showed enhanced dissolution rate was easily manipulated by changing the...

Graphic with the test results of different amorphous solid dispersions
19. February 2018
The effects of tablet preparation and subsequent film coating with amorphous solid dispersion (ASD) particles that were composed of a drug with poor water solubility and hydrophilic polymers were investigated. ASD particles were prepared with a drug and vinylpyrrolidone–vinyl acetate copolymer (PVPVA) or polyvinylpyrrolidone (PVP) at a weight ratio of 1:1 or 1:2 using a melt extrusion technique. Tablets were prepared by conventional direct compression followed by pan coating. A mathematical...

Diagram with Selective laser sintering  for 3DP tablets
18. February 2018
Abstract Selective laser sintering (SLS) is a three-dimensional printing (3DP) technology employed to manufacture plastic, metallic or ceramic objects. The aim of this study was to demonstrate the feasibility of SLS to fabricating novel solid dosage forms with accelerated drug release properties, and with a view to create orally disintegrating formulations. Two polymers (hydroxypropyl methylcellulose (HPMC E5) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon® VA 64)) were separately...

17. February 2018
Abstract Pharmaceutical excipients were designed originally to be pharmacologically inert. However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmacokinetics. Pharmacokinetic interactions may be caused by modulation of efflux transporter proteins, intercellular tight junctions and/or metabolic enzyme amongst others. In this study, five disintegrants from different chemical classes were evaluated for P-glycoprotein (P-gp) related inhibition and tight...

Photo of book cover of Engineering of Biomaterials for Drug Delivery Systems
16. February 2018
Here you find some abstracts of Engineering of "Biomaterials for Drug Delivery Systems - beyond Polyethylene Glycol". 1 – PEGylated “stealth” nanoparticles and liposomes Through nanomedicine, game-changing methods are emerging to deliver drug molecules directly to diseased tissue. The targeted delivery of drugs and imaging agents via drug carrier-based platforms is among the most promising of these methods. Such drug delivery systems can now be synthesized from a wide range of different...

Photos of clear gelatin capsules filled with TBA, a capsule and a surface in high resolution
16. February 2018
A common obstacle encountered in the early stages of drug development is the formulation of poorly water-soluble drugs (PWSDs). One effective approach to improve the dissolution of PWSDs is to render such drugs into their amorphous or disordered form.

Book cover of Book Amorphous Drugs
15. February 2018
The poor oral bioavailability of many active pharmaceutical ingredients (APIs) resulting from low solubility is one of the important challenges in pharmaceutical technology. Over the last two decades the number of relatively insoluble drugs has grown steadily. Nowadays it is estimated that approximately 70% of new drug candidates are characterized by poor solubility.

15. February 2018
Location: Anywhere in the Continental USA Compensation: $100-120K base salary plus 60% bonus potential and car Date: February 2018 Job Code: TH919AEP

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