In vitro and sensory tests to design easy-to-swallow multi-particulate formulations

Flexible dosing and ease of swallowing are key factors when designing oral drug delivery systems for paediatric and geriatric populations. Multi-particulate oral dosage forms can offer significant benefits over conventional capsules and tablets. This study proposes the use of an in vitro  model to quantitatively investigate the swallowing dynamics in presence of multi-particulates. In vitro results were compared against sensory tests that considered the attributes of ease of swallowing and post-swallow residues. Water and hydrocolloids were considered as suspending vehicles, while the suspended phase consisted of cellulose pellets of two different average sizes. Both in vivo  and in vitro tests reported easier swallow for smaller multi-particulates. Besides, water thin liquids appeared not optimal for complete oral clearance of the solids. The sensory study did not

highlight significant differences between the levels of thickness of the hydrocolloids. Conversely, more discriminant results were obtained from in vitro  tests, suggesting that a minimum critical viscosity is necessary to enable a smooth swallow, but increasing too much the carrier concentration affects swallowing negatively. These results highlight the important interplay of particle size and suspending vehicle rheology and the meaningful contribution that in vitro  methods can provide to pre-screening multi-particulate oral drug delivery systems before sensory evaluation.

In vitro and sensory tests to design easy-to-swallow multi-particulate formulations
Marco Marconatia, Felipe Lopezb, Catherine Tuleub, Mine Orlub,, Marco
aDepartment of Chemical and Process Engineering, Faculty of Engineering and Physical
Sciences, University of Surrey, Guildford, GU2 7XH, United Kingdom
bSchool of Pharmacy, University College London, London, WC1N 1AX, United Kingdom
In vitro and sensory tests to design eas
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