Enhancement of Flow Properties and Flowability of Pharmaceutical Excipients (MCCP) and its Effect on Tabletability

Flow properties of microcrystalline cellulose (MCC) excipients, Avicel PH 101 and Avicel PH

 102 have been compared by using Brookfield PFT. Afterwards, the effect of hydrophobic Silica

 R972 as glidant has been tested on both the excipients. Hand blending is done by mixing MCCs

 with hydrophobic silica R972 vigorously by SAC as an underlined basis for 10 minutes and

 the flow properties tests are performed. During the flow function test “as received” Avicel PH

 102 shows better flow function property as compared to “as received” Avicel PH 101. It was

 found that, with the increase in silica content there is a gradual increase in flow function of

 Avicel PH 102 silica blends whereas the Avicel PH 101 silica blends showed sudden increase

 in flow function which then lowered to negligible increase after 80% SAC. The wall friction

 angle of “as received” Avicel PH 102 shows lower values as compared to “as received” Avicel

 PH 101 while both showed a rise in wall friction angle with the inclusion of silica. However,

 bulk density of Avicel PH 101 first increases from 0% SAC to 60% SAC silica then decreases

 till 120% SAC silica. Whereas in Avicel PH 102, bulk density of silica blended samples have

 lower bulk density as compared “as received” Avicel PH 102. Tabletability is another

 parameter that has been compared by varying tablet mass (100 mg and 200 mg) and compaction

 force (0.75, 1 and 1.25 Metric ton). Tablets with more mass show higher strength and with

 increase in compactive force, there is increase in tablet strength. There is a decrease in tablet

 strength with increase in silica SAC.

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