Lipid nanoparticles: A challenging approach for oral delivery of BCS Class-II drugs

In today's drug development world, combinatorial chemistry, high-throughputscreening, and genomics have provided a technologic platform that produces a large number of new chemical entities withtherapeutic potential each year. Its outcome the new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in poor water solubility which primarily affectsthe bioavailability of orally administered drugs. Hence, the poor aqueoussolubility not only limits the drug's biological application but also challenges its pharmaceutical development. This review highlights the significant solubility problem and BCS/BDDCS formulationchoices, and importance of lipid nanoparticles (LNPs). Also, this review summarizes the fate of lipidand lipid formulations in the human body, Lymphatic transport of drugs in the human body, Challenges of lipid-based delivery, the role of lipids in the enhancement of bioavailability, Mechanism ofLipid nanoparticles and BCS class II drugs as an ideal candidate for the LNPs formulation with their significant finding in research outcomes reported by the different researchers. Based on theavailable data, the lipid nanoparticles makes this drug delivery systems as one of the promising delivery systems and will be a solution to the formulation scientist. Also, it complies the keyobjectives of Green chemistry and sustainable chemistry.
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