The Glatt CPS® Technology (Complex Perfect Spheres) is a fluid bed rotor technology for producing spherical matrix pellets with a smooth surface and high density. Typically, microcrystalline cellulose is used as a basic excipient for pelletization using the CPS® Technology . In the past extensive studies using soluble APIs (active pharmaceutical ingredient) as Metoprolol succinate  and Propranolol hydrochloride  were performed. During this study matrix pellets containing an insoluble API shall be developed whereby a high drug load was envisaged (not less than 50 %). Furthermore, the particles shall be as spherical as possible, and the D90 value of the particle size distribution should not exceed 400 μm.
By using the Glatt CPS®-Technology it was possible to develop spherical pellets using a water-insoluble API with a high drug load and the targeted particle size distribution. The pellets showed a spherical shape and smooth surface and the reproducibility of the process was demonstrated.
Contrary to former studies [2, 3] the CPS® Technology was used as a stand-alone unit without pre-mixing of the powders in a high-shear granulator and drying using a fluidbed unit. Nonetheless, the pellets were built and dried within short process times. Data obtained are a profound basis for further studies using APIs with different physicochemical characteristics such as solubility and particle size distribution.
Interested in more Information? Get in touch with us!