Polymers and surfactants impact stability and long-term performance.

Access to high-throughput synthesis and screening technologies has enabled the discovery of novel classes of small molecules that exhibit high potency. Unfortunately, many of these compounds suffer from poor solubility and bioavailability when administered in conventional solid-dosage forms, the preferred route of administration due to convenience and ease of use. Formulation as amorphous solid dispersions (ASDs)–most commonly via spray drying (SD) or hot-melt extrusion (HME) and more recently co-precipitation (CP)–is increasingly used to improve the performance of poorly soluble drugs. The choice of excipients for spray-dried formulations has a direct impact on the stability and efficacy of these ASDs.

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