Abstract: The recently proposed by the authors numerical approach to modelling of drug release from polymersome nanoparticles based on PNIPAM-g-PEO graft copolymer is generalized on the basis of different model dependent methods. It takes into account the specific features of the experimental procedure and equipment used during the experimental study of the drug release kinetics. The rate parameters are numerically evaluated when fitting each model curve to the available experimental data for indomethacin. Numerical simulation of drug release for 5% and 20% ethanol content is performed and the reliability of the used approach is discussed. It is established that the drug release rate is strongly influenced by the ethanol content. The considered numerical approach enables modeling of different drugs release under the same experimental equipment as well as inclusion of some new model functions describing other mechanisms controlling the release kinetics.