Herein, interfacial interactions of amorphous solid dispersion formed by nitrendipine (TDP) and two types of water-soluble polymers (polyvinyl pyrrolidone K30 (PVP) and polyethylene glycol 6000 (PEG)) were tracked mainly concerning with interaction forces and wetting process. Infrared spectroscopy (IR), Raman spectroscopy and contact angle instrument were mainly used through the study. Hydrogen bonding forces were formed between drug and excipient in TDP-PVP and TDP-PEG. The red raman shift of TDP-PVP and TDP-PEG confirmed the hydrogen bonding forces between TDP and the two polymers. Both TDP-PVP and TDP-PEG showed higher drug release and TDP-PVP accomplished TDP release faster due to its better drug amorphous state. It is believed that the track of interfacial interactions will certainly become powerful tools to provide valuable instruction for designing and evaluating amorphous solid dispersions.