Bioequivalence study of a new sildenafil 100 mg orodispersible film vs a conventional tablet

Abstract: A new orodispersible  lm formulation of the phosphodiesterase type 5 inhibitor, sildenafil, has been developed to examine the advantages of an orally disintegrating  lm formulation and provide an alternative to the current marketed products for the treatment of erectile dysfunction. The pharmacokinetics of the sildenafil 100 mg orodispersible  lm (IBSA) was compared to that of the conventional marketed 100 mg  fllm-coated tablet (Viagra®) after single-dose administration to 53 healthy male volunteers (aged 18–51 years) in a randomized, open, two-way crossover bioequivalence study. Each subject received a single oral dose of 100 mg of sildenafil as test or reference formulation administered under fasting conditions at each of the two study periods according to a randomized crossover design. There was a washout interval of 7 days between the two administrations of the investigational medicinal products. Blood samples for pharmacokinetic analysis were collected up to 24 h post-dosing. The primary objective was to compare the rate (peak plasma concentration; Cmax) and extent (area under the curve [AUC] from administration to last observed concentration time; AUC0–t) of sildenafil absorption after single-dose administration of test and reference. Secondary endpoints were observed to describe the plasma pharmacokinetic profiles of sildena fil and its metabolite N-desmethyl-sildenafil relative bioavailability and safety profile after single-dose administration. The mean sildenafil and N-desmethyl-sildenafil plasma concentration–time profiles up to 24 h after single-dose administration of sildenafil 100 mg orodispersible  lm and  film-coated tablet were nearly superimposable. The bioequivalence test was fully satisfied for sildenafil and N-desmethyl-sildenafil in terms of rate and extent of bioavailability. Adverse events occurred at similar rates for the two formula- tions and were of mild-to-moderate severity. The results suggest that the new orodispersible  lm formulation can be used interchangeably with the conventional  film-coated formulation. Keywords: sildenafll, pharmacokinetics, bioequivalence, orodispersible  film, PDE5 inhibitor, N-desmethyl-sildenafll

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Bioequivalence study of a new sildenafll 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers
Radicioni M, Castiglioni C, Giori A, Cupone I, Frangione V, Rovati S. Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers. Drug Design, Development and Therapy. 2017;11:1183-1192. doi:10.2147/DDDT.S124034.
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