Formulation and Evaluation of Immediate Release Telmisartan Tablets using Hydrophilic Polymers

Aim: Telmisartan is an anti-hypertensive drug under the class of angiotensin II receptor blocker. The aim is to formulate and evaluated immediate release telmisartan tablets using hydrophilic polymers. Materials and Method: The hydrophilic polymers are polyethylene glycol 4000 (PEG-4000) and PEG-6000. Solid dispersion is prepared with polymers with different ratios 1:0.5, 1:1, 1:2 and formulated into tablets. Formulations were characterized for drug content studies, drug release studies, and drug-polymer interactions using Fourier transform infrared spectroscopy (FTIR) spectrum. Results and Discussions: Formulation containing 1:2 ratio of drug: PEG-6000 showed the best release with a cumulative release of 99.67% as compared to 74.36% for the PEG- 4000. The FTIR studies showed that there is no interaction between the drug and polymer. Conclusion: Based evaluation of different parameters it was concluded that formulation of immediate release tablets of telmisartan was successfully done and F6 shows 100% at 60 min.

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Formulation and Evaluation of Immediate Release Telmisartan Tablets using Hydrophilic Polymers
S. Swati, N. Jyothi, P. Manjusha, N. Lakshmi Prasanthi, B. Thireesha
Department of Pharmaceutics, Nirmala College of Pharmacy, Atmakur (V), Guntur, Andhra Pradesh, India
Asian Journal of Pharmaceutics • Jan-Mar 2017 • 11 (1) | 37
1041-2537-1-PB.pdf
Adobe Acrobat Document 2.3 MB

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