• Drivers for continuous secondary OSD
• Technical barriers for implementation
• TSG case study ( residence time distribution and process
understanding examples)
• Proposed focus areas for future platform evolution

The pharmaceutical industry is under tremendous pressure to change. For manufacturing and product development, industry is striving to deliver :

• Enhanced product quality, quality assurance and process robustness
• Small flexible manufacturing footprint at low cost and environmental impact
• Minimised development and technical transfer costs and resources.

This has driven a move towards continuous OSD manufacturing. This presentation will review drivers for change, some of the technical barriers to implementation with reference to a TSG case study. It will conclude with a perspective on areas for focus in the future.
Richard Elkes
R&D continuous secondary OSD engineering lead
GSK

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