Traditional concepts of batch processing have given way to new paradigms in continuous processing for the manufacturing solid oral products. This transition from batch manufacture to continuous, flow-through systems requires development of new technologies, devices, procedures, control systems and release strategies. This requires a new understanding of both the theoretical and practical aspects of the most common unit operations and redefines the way products are developed and commercialized. This presentation will provide an overview of the design and development activities within Pfizer that led to the development of continuous processing systems and at the same time adapting them to target commercial products. The examples shown should provide insight to both the conceptual understanding of continuous processing systems and the data-driven approaches that were fundamental to the development of Pfizer’s portable, continuous processing module.