The superdisintegrants Primojel® (sodium starch glycolate) and Primellose® (croscarmellose sodium) are cross-linked and substituted polymers of glucose. The degree of cross-linking and substitution are
important factors in determining the effectiveness of these materials as superdisintegrants. In the case of Primojel®, the selection of the type of starch is also a key factor, and in the case of Primellose®, particle size is important. This introduction to the chemistry and performance of superdisintegrants describes how the synthetic processes have been optimised to ensure peak performance of these two materials.