Abstract

The purpose of this study was to compare the chemical and physical stability of amorphous solid dispersions of Ritonavir formulated with either AFFINISOL™ HPMC HME 15LV or copovidone at 3 drug loads when placed on accelerated stability testing for a period of 6 months. Additionally, dissolution performance of the resulting amorphous solid dispersions before and after stability testing was analyzed to investigate the impact of storage and drug load on performance maintenance with each polymer.