Expanding hot-melt extrusion basedabuse-deterrent formulation technology fromextended release (ER) to immediate release (IR) application
Misuse and Abuse of Prescription Drugs
Prescription pain relievers are safe and effective when used correctly for a medical condition and under a doctor’s supervision. But they can cause serious side effects if not used correctly. Incorrect use or use for non-medical reasons can lead to abuse, addiction and even death1).
SAMHSA recently reported results from their 2014 Survey on Drug and Health2). About 4.3 million people age twelve and older reported nonmedical use of prescription pain relievers including opioid-contain- ing drugs such as hydrocodone (Vicodin®), oxycodone (OxyContin®, Percodan®, Percocet®), and fentanyl (Duragesic®) during the past month2).
Expanding hot-melt extrusion based abuse-deterrent formulation technology from extended release (ER) to immediate release (IR) application
A. Kraus, PhD*); K. Wening, PhD+); S. Schwier, PhD+); H.-J. Stahlberg, MD+); E. Galia, PhD+); M. Sokolowska, PhD*)
+) Grünenthal GmbH, D-52078 Aachen, Germany; *) Grünenthal USA, Inc., Morristown, New Jersey 07960, USA
+) Grünenthal GmbH, D-52078 Aachen, Germany; *) Grünenthal USA, Inc., Morristown, New Jersey 07960, USA