This study assesses the solid-solid interactions between the commercial form of Ketoprofen (KET), a non- steroidal anti-inflammatory drug of the propionic acid class, and several widely used pharmaceutical excipients. The work was carried out on drug-excipient mixtures, in 1:1 (w:w) ratio, blended in an agate mortar at room temperature. The compatibility/incompatibility of KET with the proposed excipients was highlighted by the most commonly used analytic methods: differential scanning calorimetry (DSC), Fourier transformed infrared spectroscopy (FT-IR) and powder X-ray diffraction (PXRD). The interactions between KET and three of the excipients, namely Macrogol 6000, magnesium stearate dehydrate and lactose monohydrate were evidenced by DSC and further confirmed by FT-IR and PXRD analysis.

Keywords: Ketoprofen, excipients, thermal analysis, FT-IR spectroscopy, X-ray diffraction

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