The major challenge in pharmaceutical research is the improvement of drug efficacy, including enhancement of solubility and permeability, leading to an improved oral bioavailability of drugs. Semi-Synthetic Biopolymer Complexes (SSBC) as drug nano-enabled delivery systems have gained significant interest in recent years. Their significance originated from the fact that they show great potential as drug nano-carriers used for oral drug delivery. This resulted from their exceptional properties obtained by merging the properties of synthetic (e.g. good thermal and mechanical properties) with natural polymers (e.g. biocompatibility); thus forming a new class of biopolymeric materials combining the best of both aspects.