ABSTRACT

The goal in drug delivery research is to meet therapeutic needs relating to particular pathological conditions by developing new formulations. Research in the chronopharmacological field has demonstrated the importance of biological rhythms in drug therapy, and this has brought a new approach to the development of oral drug delivery systems. Chronotherapeutics is the discipline concerned with the delivery of drugs according to the intrinsic activities of a disease over a certain period of time because the biochemicals, physiological and pathological variations over a 24 h period in humans have been occurred. Chronotherapeutics deals with the medical treatment according to the human daily working cycle that corresponds to a person’s daily, monthly, seasonal or yearly biological clock or in order to maximize the health benefits and minimize the adverse effects. The main goal of chronotherapeutics is to match the timing of treatment with the intrinsic timing of illness. Optimum therapy is given when the right amount of drug is delivered to the correct target organ at the most appropriate time. If symptoms of a disease are varied the circadian rhythms also varied the drug release. In the treatment of many diseases chronotherapeutics drug delivery offers a new approach in the pharmacologic interventions design for the effective treatment in the different types of diseases. The “chronotherapeutics” term is mainly new in the field of drug delivery and in the treatment method. It is defined as the widespread term in which disease follow the circadian rhythm which undergoes the metabolic changes.