ANALYSIS OF PHARMACEUTICAL EXCIPIENT MCC AVICEL PH102 USING COMPACTION EQUATIONS
Abstract: This paper focuses on the characterization of the tabletting process and analysis one of the most common pharmaceutical excipients MCC Avicel PH102 by Heckel, Kawakita, Cooper-Eaton and Adams compaction equations. Experimental material was determined by measuring its parameters as particle size distribution, angle of wall friction and flow properties and for more detailed characteristics of the material particles, microscopy images of the powder before and after compressing were created.
PECIAR Peter1, ECKERT Maroš1, FEKETE Roman1, HRNČIAR Viliam2
1Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Institute of Process Engineering, Nám. Slobody 17, 812 31 Bratislava, Slovakia, e-mail: [email protected], [email protected], [email protected]
2Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Institute of Technologies and Materials, Pionierska 15,831 02 Bratislava, Slovakia, e-mail: [email protected]
1Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Institute of Process Engineering, Nám. Slobody 17, 812 31 Bratislava, Slovakia, e-mail: [email protected], [email protected], [email protected]
2Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Institute of Technologies and Materials, Pionierska 15,831 02 Bratislava, Slovakia, e-mail: [email protected]