Applications of SYLOID® FP silica in Oral Dry Suspension of Antibiotics

• Unique silica helps to protect antibiotic formulations from moisture
• Helps enhances the storage stability and shelf life of finished dosage forms
• Helps improves the flow and liquid dispersion properties of powder formulations

Βeta-lactam antibiotics such as Amoxicillin, cefuroxime, and Cefixime are often formulated with Potassium Clavulanate to avoid degradation from β-lactamase enzymes. Potassium Clavulanate is highly hygroscopic in nature and is hydrolyzed in the presence of moisture, which ultimately affects the efficiency of the antibiotics. As a result, β-lactam antibiotics are primarily formulated as dry powders which can be easily converted to liquid suspension before administration. However, the challenge is to stabilize both Potassium Clavulanate and β-lactam antibiotics in dry powder form.

More