Lipid-based drug delivery is increasingly being used to tackle oral bioavailability challenges resulting from poor solubility. This type of formulation exploits the body’s lipid disgestion and absorption pathways. 

“Many poorly soluble drugs are associated with a positive food effect in that their bioavailability increases with food intake,” observes Kaspar van den Dries, senior director formulation sciences, solid dosage forms, and softgels at Patheon. “This endogenic effect of food makes lipid systems a suitable formulation option to enhance the bioavailability of poorly soluble drugs.”

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