The present investigation is an attempt to design and evaluate rapidly dissolving oral strips of metoprolol succinate, an anti-hypertensive agent. Rapidly dissolving oral strips were prepared by solvent casting technique using hydroxyl propylmethylcellulose-5 cps and polyvinyl alcohol as the lm forming polymers. The prepared strips were evaluated for the characteristics such as thickness, folding endurance, percent elongation, tensile strength, surface pH, percent drug content, in-vitro disintegration time and in-vitro dissolution pro les. All the formulations ful lled of cial criteria for evaluated parameters. The drug content of formulations was found to be in the range of 89 to 98%, disintegration time of all the formulations was found to be in the range of 17-29 sec, and in-vitro dissolution results showed 86.33 to 98.53%. The formulation F3 containing 1:3 drug-polymer ratio showed optimum performance when compared to other formulations. Hence, it was concluded from the results that, the rapidly dissolving oral strips of metoprolol succinate can be successfully developed in order to enhance the dissolution rate, there by better patient compliance and effective therapy.