The present study is on Meclizine HCL orally disintegrating tablets. meclizine HCL is used for the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections. meclizine HCL is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Natural super disintegrates like xanthum gum and algenic acid are added to the formula to increase its disintegration, Orodispersible tablets of Meclizine Hcl were formulated by the Natural Superdisintegrant addition method by direct compression technique. All the formulations were evaluated for disintegration time, hardness and friability, this Superdisintegrant addition method exhibits the lowest disintegration time 29 sec, hence it is ranked as the best among the methods. All the formulations were evaluated for weight variation 226.3, hardness 5.1 , friability 0.29, drug content uniformity 99.5, wetting time 28 sec for in-vitro dissolution study. Among all the formulations containing naturally super disintegrates like algenic acid and xanthum gum was considered to be the best formulation, which release up to 99.6% of the drug in 20 mints.