Flow and compaction properties of hypromellose: new directly compressible versus the established grades
Context: Information about flow and compaction properties of hypromellose (HPMC) polymers is essential for technologists who are facing challenges regarding poor flow and compaction while developing new controlled release matrix tablets. There is a profound lack of studies in this field and none of the published ones deal with the compaction of the newly introduced HPMC grades specifically designed for direct compression (DC). Objective: The objective behind this study was the evaluation of flow and compaction properties of six different grades of HPMC substitution type 2208 polymers, including two second generation directly compressible grades from Dow Chemical Company (K100LV, K15M, K4M CR, K4M DC, K100M CR and K100M DC).
, , . (2018) High-shear granulation of high-molecular weight hypromellose: effects of scale-up and process parameters on flow and compaction properties. Drug Development and Industrial Pharmacy 44:11, pages 1770-1782.