In order to target celecoxib which is a COX2 inhibitor, with potentials in the prevention and treatment of colitis and colon cancer, it was formulated as microparticles using solvent/evaporation method and various pH dependent Eudragit polymers .The in-vitro evaluation of the prepared microparticles showed spherical and smooth morphology. The encapsulation efficiency and yield were high indicating that the method used is simple and efficient at this scale. The in-vitro release study showed no release in acidic medium for 2 hr followed by the release of the drug in pH 6.8 in case of Eudragit L100-55 and L100 and pH 7.4 in case of Eudragit S100.

Keywords: Colon targeting, Microparticles, Celecoxib, Pharmacokinetic Parameters, Acetic acid induced colitis

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