The most prevalent pharmaceutical dosage forms at present––the oral immediate-release tablets and capsules––are granular solids. Though effective in releasing drug rapidly, development and manufacture of such dosage forms are fraught with difficulties inherent to particulate processing. Predictable dosage form manufacture could be achieved by liquid-based processing, but cast solid dosage forms are unsuitable for immediate drug release due to their resistance to fluid percolation. To overcome this limitation, accordingly, we have recently introduced cellular dosage forms that can be readily prepared from polymeric melts. It has been shown that open-cell structures comprising polyethylene glycol 8,000 (PEG 8k) excipient and a drug exfoliate upon immersion in the dissolution medium.

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