A pharmaceutical compound was used to study the effect of batch wet granulation process parameters in combination with the residual moisture content remaining after drying on granule and tablet quality attributes. The effect of three batch wet granulation process parameters was evaluated using a multivariate experimental design, with a novel constrained design space. Batches were characterised for moisture content, granule density, crushing strength, porosity, disintegration time and dissolution.

Keywords: Granulation; Drying; Compression; Compaction; Granule; Tablet; Moisture; Water; Hardness; Tensile strength; Dissolution; Porosity; Density; Specific energy

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