Drug Delivery Systems Obtained from Silica Based Organic-Inorganic Hybrids
This is a review of hybrid materials based on silica as an inorganic phase used as drug delivery systems (DDS). Silica based DDS have shown effectivity when compared with traditional delivery systems. They present advantages such as: (a) ability to maintain the therapeutic range with minor variations; (b) prevention of local and systemic toxic effects; (c) plasma concentrations increase of substances with a short half-life; and (d) reduction of the number of daily doses, which may increase patient adherence to the treatment. These advantages occur due to the physical, chemical and optical properties of these materials. Therefore, we discuss the properties and characteristics of them and we present some applications, using different approaches of DDS to ensure therapeutic effectiveness and side effects reduction such as implantable biomaterial, film-forming materials, stimuli-responsive systems and others.
Keywords: organic-inorganic materials; drug delivery systems; sol-gel process
Bruna Lallo da Silva 1, Bruna Galdorfini Chiari-Andréo 1,2 and Leila Aparecida Chiavacci 1,*
1 Faculdade de Ciências Farmacêuticas, UNESP—Univ Estadual Paulista, Araraquara-Jaú, Km 1,
Araraquara 14800-903, Brazil; [email protected] (J.A.O.J.); [email protected] (M.P.A.);
[email protected] (E.B.M.); [email protected] (B.L.S.);
[email protected] (B.G.C.-A.)
2 Departamento de Ciências Biológicas e da Saúde, Centro Universitário de Araraquara—UNIARA,
Araraquara 14800-903, Brazil
* Correspondence: [email protected]; Tel.: +55-16-3301-6966; Fax: +55-16-3301-6900
Academic Editor: Jianxun Ding
Received: 22 February 2016; Accepted: 10 March 2016; Published: 24 March 2016