In silico product design of pharmaceuticals

24. March 2016

The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms. As the number of possible dosage forms may scale towards infinity, their uniqueness require a versatile production platform and numerical simulation in order to be manufactured efficiently.

A mathematical description of these systems is the only feasible approach to manage such diverse properties of different products. However, experimental verification is still essential for evaluation of processability and related concomitant phenomena, such as possible solid state changes that may occur during production and storage.

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Keywords: Personalized medicine; simulation; rheology; imaging; continuous manufacturing; extrusion

Johan Boetker, Dhara Raijada, Johanna Aho, Milad Khorasani, Søren V. Søgaard, Lærke Arnfast, Adam Bohr, Magnus Edinger, Jorrit J. Water, Jukka Rantanen, In silico product design of pharmaceuticals, Asian Journal of Pharmaceutical Sciences, Volume 11, Issue 4, 2016, Pages 492-499, ISSN 1818-0876, https://doi.org/10.1016/j.ajps.2016.02.010.
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