Durio zibethinus L. (Malvaceae) also known as “Durian” in the Philippines is an evergreen tropical tree found mainly in the regions of Mindanao and Sulu. One-fourth of the fruits’ mass is composed of seeds which is usually discarded [1]. This study aimed to determine the binding efficacy of extracted Puyat variety of Durian seed gum in Paracetamol tablet formulation. Durian seed gum was extracted consecutively using petroleum ether, ethanol and 1% acetic acid. Yielded seed gum extract was characterized in terms of its physicochemical properties. An acute oral toxicity study was done. Differential scanning calorimeter was used to test the compatibility of Durian seed gum with Paracetamol and its excipient. Different batches of Paracetamol tablet was formulated using Durian seed gum, PVP K-30, Acacia, and Corn starch as binder. Physical evaluation was done on the Paracetamol granules and comparative analysis showing the effectiveness of Durian seed gum in contrast with standard binders was evaluated through quality control tests like hardness, friability, disintegration, and dissolution test. The result of the study showed that Durian seed gum possesses good physicochemical properties.

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