Electrochemical evaluation of antioxidant capacity in pharmaceutical antioxidant excipient of drugs on guanine-based modified electrode
The aim of this study is to propose a new electrochemical method for the evaluation of the antioxidant capacity of the pharmaceutical antioxidant excipient in drugs. The evaluation was conducted by integrity testing of DNA bases, which were modified on an electrode. Guanine was selected as the electrochemical probe. Based on the changes of the oxidation current of guanine on a modified glassy carbon electrode (GCE), the protective capacity of the antioxidant for guanine was determined. TiO2 nanoparticles (TiO2NPs) adhering to maltiwalled carbon nanotubes (MWCNTs) were used for guanine oxidation via photo generating hydroxyl radicals.
Keywords: Hydroxyl radicals; Antioxidant capacity; Guanine biosensor; TiO2 nanoparticles; Drug; Pharmaceutical antioxidant excipient