Simethicone is viscous, greyish-white, opalescent preparation used as anti foaming agent to prevent formation of gas in gastro intestinal tract. As per USP, it is a mixture of fully methylated linear siloxane polymers containing repeating units of the formula [–(CH3)2SiO–]n, stabilized with trimethylsiloxy end-blocking units of the formula [(CH3)3 SiO–], and silicon dioxide. It contains not less than 90.5 percent and not more than 99.0 percent of polydimethylsiloxane ([–(CH3)2SiO–]n), and not less than 4.0 percent and not more than 7.0 percent of silicon dioxide. 

Chewable tablets are preferred by most of the formulators for addressing the ailments related to GIT specially digestion. For Simethicone being viscous in nature, formulators find it challenge to make tablets of liquid Simethicone. Syloid® 244FP silica being highly porous can convert viscous Simethicone into compressible free flowing powder. The detailed formulation and role of Syloid® 244FP silica in Simethicone chewable tablet preparation is discussed in detail below.

Keywords: Syloid 244FP, silica, chewable tablet, excipient, Simethicone