Solubility parameters of hypromellose acetate succinate and plasticization in dry coating procedures
Solubility parameters of HPMCAS have not yet been investigated intensively. On this account total and three dimensional solubility parameters of HPMCAS were determined by using different experimental as well as computational methods. In addition, solubility properties of HPMCAS in a huge number of solvents were tested and a Teas plot for HPMCAS was created. The total solubility parameter of about 24 MPa0.5 was confirmed by various procedures and compared with values of plasticizers. 20 common pharmaceutical plasticizers were evaluated in terms of their suitability for supporting film formation of HPMCAS under dry coating conditions.
Keywords: Coating efficiency, contact angle, film formation, glass transition temperature, intrinsic viscosity, inverse gas chromatography, Myvacet® 9-45K, triethyl citrate
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