The main purpose of this study was to increase the solubility of poorly soluble drug by preparing solid

dispersions. Nifedipine (poorly water soluble drug), when prepared as solid dispersion showed increased solubility and dissolution rate. Solid dispersions of Nifedipine were prepared by using silsol 6035 as carrier in various proportions 10%, 20% and 30% by solvent loading (solvent droplet addition)method and various grades of silica by co-milling method in ratios of (1:1, 1:2 and 2:1). The drug carrier interactions were carried out using Differential Scanning Calorimetry (DSC). Drug release and dissolution profile was studied and it was found that the percentage release of the drug for solid

dispersions samples was found to be higher than those of the pure milled drug and co-milled powders.

Keywords: Nifedipine, solid dispersion, co-milling, solvent loading, Syloid, Silsol