Drug – delivery interaction studies were done for loperamide (Lp) loaded surfactant liposomes (LpLc) using FTIR ,DSC , XRD and SEM. Early researches have used Lp and liposomes for brain targeting programme but not have done any interaction studies .We have investigated presence of any drug degradative  interactions with the excipient ( drug delivery – Liposomes) using FTIR , DSC , XRD and SEM analytical techniques. Our results suggests that presence of characteristic IR absorption peaks of Lp in LpLc in FTIR study confirmed absence of any drug interactions. Absence of Drug endothermic peak in DSC of LpLc indicates the amorphous nature of entrapped Lp . SEM ensured the absence of any undissolved drug or particles. XRD supports the existence of Lp in the LpLc without any drug interaction. In conclusion , drug loperamide (Lp) does not showed any degradative  interactions with the carrier or excipient. Thus these studies supports the safety and efficient usage of Liposomes for Lp .