Preparation of Bitter Taste-Masking Granules of Lafutidine for Orally Disintegrating Tablets using Water-Insoluble/Soluble Polymer Combinations
Taste-masking granules were prepared by coating granules with a taste-masking layer prepared by combining the water-insoluble and -soluble polymers, ethylcellulose and hypromellose, respectively. These granules showed an immediate drug release property after a suitable lag time. We confirmed that the dissolution behavior depended on the polymer ratio in the taste-masking layer. The result showed that the dissolution lag time and rate of the taste-masking granules were shortened and enhanced, respectively by increasing the hypromellose content.