Effect of precipitation/re-dissolution processes from the supersaturated solution on the intestinal absorption of poorly water-soluble drugs
As one of the possible technologies to improve the oral absorption of poorly water-soluble drugs, supersaturable formulation is now attracting the attention which enables to dissolve the drug to the higher concentration than their equilibrium solubility [1]. Those include salt-formation, solid-dispersion, co-crystallization or the use of amorphous form. Since supersaturation is a thermodynamically metastable state, supersaturated solution has a high potential to precipitate.