Various techniques are being followed to achieve increased solubility of the drug compounds depending upon active pharmaceutical ingredients (API) characteristics, formulator’s capabilities, and relative cost effectiveness of the strategies. Among advanced solubility enhancement technologies, the most important ones are solid dispersions and lipid solubilization. In fact, lipid excipients are the largest category of solubility enhancement excipients because of their large levels of use in drug formulations and their ability to increase the solubility of lipophilic active ingredients. Polymers come in second due to the increasing use of solid dispersion technologies.

More