Highlights

• Development of a new biorelevant dissolution method for orodispersible films, considering mechanical force, saliva flow, volume and composition.
• Comparison of different conventional methods and the new biorelevant dissolution method regarding their consideration of in vivo conditions.
• Feasibility and problems of different dissolution setups for orodispersible films.
• Conventional dissolution setups show faster concentration onset compared to the new developed biorelevant setup.
• The simulated saliva flow has a higher impact on the dissolution of orodispersible films compared to the mechanical force.

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