Fish collagen-based scaffold containing PLGA microspheres for controlled growth factor delivery in skin tissue engineering
Highlights
• A GF release system was consisted of fish Col/Ch/CS scaffold and PLGA MPs.
• The release rate could be adjusted by the ratio of collagen to chitosan and the size of MPs.
• The released bFGF retained its structure integrity and bioactivity.
• The scaffolds/MPs could promote cell proliferation and tissue regeneration.
• This scaffold/MP release system has the potential for skin tissue engineering.