Syloid® XDP silica – New Application Note on Solid delivery of PEG drug solubilizers – Whitepaper

22. September 2015

Syloid® XDP silica: Carrier for liquid drug solubilizers in solid dosage form.

The solubility of poorly soluble drugs can be increased by using solubilizers such as polyethylene glycols (PEG), Tween 80 etc. These solublizers can be used to increase oral bioavailability of class II and class IV drugs. Often, these solubilizers are liquid in nature and can be challenging to formulate into solid dosage forms such as tablets and capsules. To address this, soft gelatin capsules have been used to deliver liquids. However, higher manufacturing time, poor yields and more required resources make soft gelatin capsules very costly.

Highlights

• Solid carrier for PEG-based drug delivery systems
• Transform liquids to easy to handle solids
• Increase liquid loading in solid dosage forms
• Release API completely from solid dosage forms

Syloid® XDP silicas are mesoporous, amorphous, silica gels with a unique morphology that create an excellent solid porous carrier for pharmaceutical formulations 1,2. The combined adsorption capacity, porosity, particle size, and density provide a tool to convert liquid ingredients into free flowing powder. The obtained liquid loaded Syloid® XDP silica creates formulations that are easy to manufacture and help improve efficacy of the final dosage form. In this application note, the role of Syloid® XDP silica as an adsorbent carrier is evaluated for delivery of PEG 400-drug solution in solid dosage forms.

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AP019_Syloid XDP- carrier for PEG_Nifedi

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Materials

Nifedipine was used as model poorly soluble drug. The Syloid® XDP 3050 silica used was from W. R. Grace & Co. All other excipients and chemicals used were Pharma grade and from leading manufacturers. The saturated solution of Lifedipine was prepared in PEG 400. The obtained solution (1.5ml) was adsorbed on 1gm of Syloid® XDP silica in a beaker with simultaneous mixing. On a larger scale, the solution can be sprayed on Syloid® XDP silica to ensure uniform adsorption. The obtained powder was evaluated by dissolution study using USP apparatus II.

excipients formulation