Drug-Excipient Compatibility for the Formulation Development of Solid Lipid Nanoparticles

Solid lipid nanoparticles (SLN) are a type of a carrier system that employs solid lipids as a matrix for drug delivery.1 The drug is molecularly dispersed within the lipid matrix, and the system is stabilized with an emulsifier.2 Nanoparticles distributed within the matrix usually have a mean particle size between 50 and 1000 nanometers.3,4 This reduction in particle size along with drug incorporation throughout the lipid matrix provides relevant pharmaceutical features to SLN as a drug delivery system. 

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