Phospholipid-based solid drug formulations for oral bioavailability
Low bioavailability nowadays often represents a challenge in oral dosage form development. Solid formulationscomposed of drug and phospholipid (PL), which, upon contact with water, eventually form multilamellar liposomes (i.e. ‘proliposomes’), are an emerging approach to solve such issue.Regarded as an ‘improved’ version of liposomes concerning storage stability, the potential and versatility of a range of such formulations for oral drug delivery have been extensively discussed.However, a systematic and quantitative analysis of the studies that applied solid PL for oral bioavailability enhancement is currently lacking. Such analysis is necessary for providing an overview ofthe research progress and addressing the question on how promising this approach can be on bioavailability enhancement.