The objective of the present study was to develop mouth dissolving tablets of meloxicam in order to achieve rapid release in saliva which may result in enhanced absorption and thereby improved bioavailability. Six batches of mixed hydrotropic solid dispersions and physical mixtures were prepared using different ratios (1:2, 1:4 and 1:6) of hydrotropic blends (urea, Nicotinamide & sodium citrate). The best batch was selected to prepare mouth dissolving tablets comprising solid dispersion of Meloxicam in six preliminary batches using croscarmellose sodium & crospovidone as superdisintegrants and camphor as subliming agent in different ratios along with other excipients. Secondary batches were prepared based on 32 factorial design with amount of superdisintegrant (crospovidone) and camphor (subliming agent) as two independent formulation variables. Two dependent response variables considered were disintegration time and percentage friability. All the batches of mouth dissolving tablets we