Non-conventional polymers as matrix excipients for hot melt extruded oral-release formulations

11. May 2015

The objective of this doctoral thesis was to evaluate the use of several non-conventional polymers as matrix excipients for hot melt extruded oral-release formulations. Expanding the range of polymers currently used for HME/IM could potentially solve the problems associated with the current formulations: pH dependent release profiles, stability issues, and low drug loaded dosage forms…